Chih-Jung Kuo
Department of Veterinary Medicine ｜ Associate Professor
論文著作
Papers
2021
1. Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LHC, Hsieh MC, Chang SY, Liang PH (2021, Jan). Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2. Antimicrobial Agents and Chemotherapy. (Accepted).
2. Chen CC#, Yu X#, Kuo CJ#, Min J, Chen S, Wu S, Ma L, Liu K, Guo RT (2021, Jan). Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases. FEBS Journal. (Accepted).
2020
3. Pathak N, Chen YT, Hsu YC, Hsu NY, Kuo CJ, Tsai HP, Kang JJ, Huang CH, Chang SY, Chang YH, Liang PH, Yang JM (2020, Dec). Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing. ACS Nano. (Accepted).
4. Theerawatanasirikul S, Kuo CJ*, Phecharat N, Chootip J, Lekcharoensuk C, Lekcharoensuk P* (2020, Oct). Structural-based virtual screening and in vitro assays for small molecules inhibiting the feline coronavirus 3CL protease as a surrogate platform for coronaviruses. Antiviral Research【Copublished with Faculty of Veterinary Medicine, Kasetsart University】
5. Wu CW, Wu TY, Kuo CJ, Lu YP, Chien MS, Huang C (2020, Jul). Characterization of the monoclonal antibody specific to the ORF72 protein of koi herpesvirus and cellular distribution analysis of the viral protein. Journal of Fish Diseases, 43(7):791-799.
6. Li T, Zhang Y, Dong K, Kuo CJ, Li C, Zhu YQ, Qin J, Li QT, Chang YF, Guo X, Zhu Y (2020, May). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. ms, 5(3):e00017-20.
7. Lin WC, Ptak CP, Chang CY, Ian MK, Chia MY, Chen TH, Kuo CJ* (2020, May). Autochthonous Lactic Acid Bacteria Isolated From Dairy Cow Feces Exhibiting Promising Probiotic Properties and in vitro Antibacterial Activity Against Foodborne Pathogens in Cattle. Frontiers in Veterinary Science, 7:239.
8. Hou FH, Lee WC, Liao JW, Chien MS, Kuo CJ, Chung HP, Chia MY (2020, Mar). uation of a type 2 modified live porcine reproductive and respiratory syndrome vaccine against heterologous challenge of a lineage 3 highly virulent isolate in pigs. PeerJ, 8:e8840. (SCI, 32/71, Multpdisciplinary Sciences).
9. Theerawatanasirikul S, Kuo CJ*, Phetcharat N, Lekcharoensuk P* (2020, Feb). In silico and in vitro analysis of small molecules and natural compounds targeting the 3CL protease of feline infectious peritonitis virus. Antiviral Research, 174:104697.【Copublished with Faculty of Veterinary Medicine, Kasetsart University】
2019
10. Kuo CJ, Gao J, Huang JW, Ko TP, Zhai C, Ma L, Liu W, Dai L, Chang YF, Chen TH, Hu Y, Yu X, Guo RT, Chen CC (2019, Sep). Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis. Biochimica et Biophysica Acta: General Subjects, 1863(9):1351-1359.
2018
11. Lin YF, Tseng IJ, Kuo CJ, Lin HY, Chiu IJ, Chiu HW (2018, Apr). High‐level expression of ARID1A predicts a favorable outcome in triple‐negative breast cancer patients receiving paclitaxel‐based chemotherapy. Journal of Cellular and Molecular Medicine, 22(4): 2458–2468.
12. Liao SW, Lee JJ, Ptak CP, Wu YC, Hsuan SL, Kuo CJ*, Chen TH* (2018, Mar). Effects of L-arabinose efflux on λ Red recombination-mediated gene knockout in multiple-antimicrobial-resistant Salmonella enterica serovar Choleraesuis. Archives of Microbiology, 200(2):219-225.
2017
13. Huang SP, Liu PY, Kuo CJ, Chen CL, Lee WJ, Tsai YH, Lin YF. (2017, Jun). The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer.. Journal of Hematology & Oncology, 10(1):114.
14. Hsieh CL, Tseng A, He H, Kuo CJ, Wang X, Chang YF. (2017, May). Leptospira Immunoglobulin-like Protein B Interacts with the 20th Exon of Human Tropoelastin Contributing to Leptospiral Adhesion to Human Lung Cells. . Frontiers in Cellular and Infection Microbiology, 7:163.
15. Liao SW, Lee JJ, Chen F, Lee WC, Wu YC, Hsuan SL, Kuo CJ, Chang YC, Chen TH (2017, May). uation of Lung Scoring and Serological Analysis of Actinobacillus pleuropneumoniae Infection in Pigs. Pakistan veterinary journal , (16):359-363.
16. Gao J, Huang JW, Li Q, Liu W, Ko TP, Zheng Y, Xiao X, Kuo CJ, Chen CC, Guo RT. (2017, Apr). Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris. Enzyme and Microbial Technology, 99:32-37.
2016
17. Wu YC, Chen CM, Kuo CJ, Lee JJ, Chen PC, Chang YC, Chen TH (2016, Nov). Prence and molecular characterization of Clostridium difficile isolates from a pig slaughterhouse, pork, and humans in Taiwan. International Journal of Food Microbiology, 242,37–44.
18. Huang JW, Liu W, Lai HL, Cheng YS, Zheng Y, Li Q, Sun H, Kuo CJ, Guo RT, Chen CC (2016, Sep). Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50. Biochemical and Biophysical Research Communications , 478(2),565–572.
19. Lee JJ, Wu YC, Kuo CJ, Hsuan SL, Chen TH (2016, Sep). TolC is important for bacterial survival and oxidative stress response in Salmonella enterica serovar Choleraesuis in an acidic environment. Veterinary Microbiology, 193(2019),42-48.
2015
20. Lee JJ, Hsuan SL, Kuo CJ, Wu YC, Chen TH (2015, Dec). MarA and ramA regulate virulence in Salmonella entericaserovar Choleraesuis. Veterinary Microbiology, 181 (2015) 323–327.
21. Kuo CJ*, Liang PH* (2015, Mar). Characterization and Inhibition of the 3C-like Protease of Severe Acute Respiratory Syndrome Coronavirus. ChemBioEng Reviews, 22(2):118–132.
22. Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y. (2015, Jan). Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins, Jan;83(1):37-45. doi: 10.1002/prot.24618.
2013
23. Kuo CJ, Ptak CP, Hsieh CL,Akey BL , Chang YF (2013, Feb). Elastin, a Novel Extracellular Matrix Protein Adhering to Mycobacterial Antigen 85 Complex. Journal of Biological Chemistry, 288(6),3886-96.
2012
24. Chang KM, Chen SH, Kuo CJ, Chang CK, Guo RT, Yang JM, Liang PH. (2012, Apr). Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis. Biochemistry, 51 (16),3412–3419.
25. Kuo CJ, Bell H, Hsieh CL, Ptak CP, Chang YF (2012, Jan). Novel Mycobacteria antigen 85 complex binding motif on Fibronectin. Journal of Biological Chemistry, 287(3),1892-902.
2011
26. Teng KH, Chen AP, Kuo CJ, Li YC, Liu HG, Chen CT, Liang PH (2011, Oct). Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time. Analytical Biochemistry, 417(1),136-41.
27. Wen CC, Shyur LF, Jan JT, Liang PH, Kuo CJ, Arulselvan P, Wu JB, Kuo SC, Yang NS. (2011, Aug). Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. Journal of Traditional and Complementary Medicine, 1(1),41-50.
28. Lin YP, Kuo CJ, Koleci X, McDonough SP, Chang YP (2011, Feb). Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding. The Journal of Biological Chemistry, 286(5),3957-69.
2010
29. Ahn TY, Kuo CJ, Liu HG, Ha DC, Liang PH, Jung YS (2010, May). Synthesis and uation of Benzoquinolinone Derivatives as SARS-CoV 3CL Protease Inhibitors. The Korean Chemical Society, 31(1),1-5.
2009
30. Kuo CJ, Shih YP, Kan D, Liang PH (2009, Dec). Engineering a novel endopeptidase based on SARS 3CLpro. Biotechniques, 47 (6),1029-1032.
31. Lee CC#, Kuo CJ#, Ko TP, Hsu MF, Tsui YC, Chang SC, Yang S, Chen SJ, Chen HC, Hsu MC, Shih SR, Liang PH, Wang AH (2009, Mar). Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. The Journal of Biological Chemistry, 284(12),7646-7655.
2008
32. Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH. (2008, Aug). Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. Journal of Biomedicine and Biotechnology, 2008,841312.
33. Kuo CJ, Liu HG, Lo YK, Seong CM, Lee KI, Jung YS, Liang PH (2008, Aug). Individual and common inhibitors of coronavirus and picornavirus main proteases. FEBS Letters, 583(3),549-55..
34. Kuo CJ, Shie JJ, Fang JM, Yen GR, Hsu JT, Liu HG, Tseng SN, Chang SC, Lee CY, Shih SR, Liang PH (2008, Aug). Design, synthesis, and uation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorganic & Medicinal Chemistry, 16(15),7388-98.
2007
35. Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH (2007, Nov). Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Letters, 581(28),5454-8.
36. Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS (2007, Aug). Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of Medicinal Chemistry, 50(17),4087-95.
37. Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. (2007, Jun). Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases.. Proceedings of the National Academy of Sciences, 104(24),10022-7.
2006
38. Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ, Tsai KC, Hsieh HP, Chao YS, Wu SY (2006, Aug). Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. Journal of Medicinal Chemistry, 49(17),5154-61.
39. Wu CY, King KY, Kuo CJ, Fang JM, Wu YT, Ho MY, Liao CL, Shie JJ, Liang PH, Wong CH (2006, Mar). Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chemistry & Biology , 13(3),261-8.
2005
40. Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH (2005, Dec). Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. Journal of Bacteriology , 187(23),8137-48.
41. Hsu MF#, Kuo CJ#, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wang AH, Liang PH (2005, Sep). Mechanism of the maturation process of SARS-CoV 3CL protease. The Journal of Biological Chemistry, 280(35),31257-66.
42. Shie JJ, Fang JM, Kuo TH, Kuo CJ, Liang PH, Huang HJ, Wu YT, Jan JT, Cheng YS, Wong CH (2005, Sep). Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorganic & Medicinal Chemistry, 13(17),5240-52.
43. Chen LR, Wang YC, Lin YW, Chou SY, Chen SF, Liu LT, Wu YT, Kuo CJ, Chen TS, Juang SH (2005, Jun). Synthesis and uation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorganic & Medicinal Chemistry Letters , 15(12),3058-62.
44. Shie JJ, Fang JM, Kuo CJ, Kuo TH, Liang PH, Huang HJ, Yang WB, Lin CH, Chen JL, Wu YT, Wong CH (2005, Jun). Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. Journal of Medicinal Chemistry, 48(13),4469-73.
45. Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005, May). Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. The Journal of Biological Chemistry, 280(21),20762-74.
2004
46. Hsu JT, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CP, Huang PF, Chen X, Liang PH (2004, Sep). uation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Letters, 574(1-3),116-20.
47. Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YS, Hsu HH, Huang HC, Wu D, Brik A, Liang FS, Liu RS, Fang JM, Chen ST, Liang PH, Wong CH (2004, Jul). Small molecules targeting severe acute respiratory syndrome human coronavirus. Proceedings of the National Academy of Sciences, 101(27),10012-7.
48. Guo RT, Kuo CJ, Ko TP, Chou CC, Liang PH, Wang AH (2004, Jun). A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry, 43(24),7678-86.
49. Kuo CJ, Chi YH, Hsu JT, Liang PH. (2004, Jun). Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochemical and Biophysical Research Communications , 318(4),862-7.
50. Guo RT, Kuo CJ, Chou CC, Ko TP, Shr HL, Liang PH, Wang AH (2004, Feb). Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. The Journal of Biological Chemistry, 279(6),4903-12.
Book Chapters
Christopher P. Ptak, Chih‐Jung Kuo, and Yung‐Fu Chang. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections Mycobacterium tuberculosis Antigen 85 Family Proteins: Mycolyl Transferases and Matrix‐Binding Adhesins (ISBN: 978-1-118-95111-8). WILEY. Nov, 2016.
Patents
Liang PH, Kuo CJ, Shih YP. Protein expression involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease. US patent number: US8053222
1. Kuo CJ, Chao TL, Kao HC, Tsai YM, Liu YK, Wang LHC, Hsieh MC, Chang SY, Liang PH (2021, Jan). Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2. Antimicrobial Agents and Chemotherapy. (Accepted).
2. Chen CC#, Yu X#, Kuo CJ#, Min J, Chen S, Wu S, Ma L, Liu K, Guo RT (2021, Jan). Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases. FEBS Journal. (Accepted).
2020
3. Pathak N, Chen YT, Hsu YC, Hsu NY, Kuo CJ, Tsai HP, Kang JJ, Huang CH, Chang SY, Chang YH, Liang PH, Yang JM (2020, Dec). Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing. ACS Nano. (Accepted).
4. Theerawatanasirikul S, Kuo CJ*, Phecharat N, Chootip J, Lekcharoensuk C, Lekcharoensuk P* (2020, Oct). Structural-based virtual screening and in vitro assays for small molecules inhibiting the feline coronavirus 3CL protease as a surrogate platform for coronaviruses. Antiviral Research【Copublished with Faculty of Veterinary Medicine, Kasetsart University】
5. Wu CW, Wu TY, Kuo CJ, Lu YP, Chien MS, Huang C (2020, Jul). Characterization of the monoclonal antibody specific to the ORF72 protein of koi herpesvirus and cellular distribution analysis of the viral protein. Journal of Fish Diseases, 43(7):791-799.
6. Li T, Zhang Y, Dong K, Kuo CJ, Li C, Zhu YQ, Qin J, Li QT, Chang YF, Guo X, Zhu Y (2020, May). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. ms, 5(3):e00017-20.
7. Lin WC, Ptak CP, Chang CY, Ian MK, Chia MY, Chen TH, Kuo CJ* (2020, May). Autochthonous Lactic Acid Bacteria Isolated From Dairy Cow Feces Exhibiting Promising Probiotic Properties and in vitro Antibacterial Activity Against Foodborne Pathogens in Cattle. Frontiers in Veterinary Science, 7:239.
8. Hou FH, Lee WC, Liao JW, Chien MS, Kuo CJ, Chung HP, Chia MY (2020, Mar). uation of a type 2 modified live porcine reproductive and respiratory syndrome vaccine against heterologous challenge of a lineage 3 highly virulent isolate in pigs. PeerJ, 8:e8840. (SCI, 32/71, Multpdisciplinary Sciences).
9. Theerawatanasirikul S, Kuo CJ*, Phetcharat N, Lekcharoensuk P* (2020, Feb). In silico and in vitro analysis of small molecules and natural compounds targeting the 3CL protease of feline infectious peritonitis virus. Antiviral Research, 174:104697.【Copublished with Faculty of Veterinary Medicine, Kasetsart University】
2019
10. Kuo CJ, Gao J, Huang JW, Ko TP, Zhai C, Ma L, Liu W, Dai L, Chang YF, Chen TH, Hu Y, Yu X, Guo RT, Chen CC (2019, Sep). Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis. Biochimica et Biophysica Acta: General Subjects, 1863(9):1351-1359.
2018
11. Lin YF, Tseng IJ, Kuo CJ, Lin HY, Chiu IJ, Chiu HW (2018, Apr). High‐level expression of ARID1A predicts a favorable outcome in triple‐negative breast cancer patients receiving paclitaxel‐based chemotherapy. Journal of Cellular and Molecular Medicine, 22(4): 2458–2468.
12. Liao SW, Lee JJ, Ptak CP, Wu YC, Hsuan SL, Kuo CJ*, Chen TH* (2018, Mar). Effects of L-arabinose efflux on λ Red recombination-mediated gene knockout in multiple-antimicrobial-resistant Salmonella enterica serovar Choleraesuis. Archives of Microbiology, 200(2):219-225.
2017
13. Huang SP, Liu PY, Kuo CJ, Chen CL, Lee WJ, Tsai YH, Lin YF. (2017, Jun). The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer.. Journal of Hematology & Oncology, 10(1):114.
14. Hsieh CL, Tseng A, He H, Kuo CJ, Wang X, Chang YF. (2017, May). Leptospira Immunoglobulin-like Protein B Interacts with the 20th Exon of Human Tropoelastin Contributing to Leptospiral Adhesion to Human Lung Cells. . Frontiers in Cellular and Infection Microbiology, 7:163.
15. Liao SW, Lee JJ, Chen F, Lee WC, Wu YC, Hsuan SL, Kuo CJ, Chang YC, Chen TH (2017, May). uation of Lung Scoring and Serological Analysis of Actinobacillus pleuropneumoniae Infection in Pigs. Pakistan veterinary journal , (16):359-363.
16. Gao J, Huang JW, Li Q, Liu W, Ko TP, Zheng Y, Xiao X, Kuo CJ, Chen CC, Guo RT. (2017, Apr). Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris. Enzyme and Microbial Technology, 99:32-37.
2016
17. Wu YC, Chen CM, Kuo CJ, Lee JJ, Chen PC, Chang YC, Chen TH (2016, Nov). Prence and molecular characterization of Clostridium difficile isolates from a pig slaughterhouse, pork, and humans in Taiwan. International Journal of Food Microbiology, 242,37–44.
18. Huang JW, Liu W, Lai HL, Cheng YS, Zheng Y, Li Q, Sun H, Kuo CJ, Guo RT, Chen CC (2016, Sep). Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50. Biochemical and Biophysical Research Communications , 478(2),565–572.
19. Lee JJ, Wu YC, Kuo CJ, Hsuan SL, Chen TH (2016, Sep). TolC is important for bacterial survival and oxidative stress response in Salmonella enterica serovar Choleraesuis in an acidic environment. Veterinary Microbiology, 193(2019),42-48.
2015
20. Lee JJ, Hsuan SL, Kuo CJ, Wu YC, Chen TH (2015, Dec). MarA and ramA regulate virulence in Salmonella entericaserovar Choleraesuis. Veterinary Microbiology, 181 (2015) 323–327.
21. Kuo CJ*, Liang PH* (2015, Mar). Characterization and Inhibition of the 3C-like Protease of Severe Acute Respiratory Syndrome Coronavirus. ChemBioEng Reviews, 22(2):118–132.
22. Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y. (2015, Jan). Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins, Jan;83(1):37-45. doi: 10.1002/prot.24618.
2013
23. Kuo CJ, Ptak CP, Hsieh CL,Akey BL , Chang YF (2013, Feb). Elastin, a Novel Extracellular Matrix Protein Adhering to Mycobacterial Antigen 85 Complex. Journal of Biological Chemistry, 288(6),3886-96.
2012
24. Chang KM, Chen SH, Kuo CJ, Chang CK, Guo RT, Yang JM, Liang PH. (2012, Apr). Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis. Biochemistry, 51 (16),3412–3419.
25. Kuo CJ, Bell H, Hsieh CL, Ptak CP, Chang YF (2012, Jan). Novel Mycobacteria antigen 85 complex binding motif on Fibronectin. Journal of Biological Chemistry, 287(3),1892-902.
2011
26. Teng KH, Chen AP, Kuo CJ, Li YC, Liu HG, Chen CT, Liang PH (2011, Oct). Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time. Analytical Biochemistry, 417(1),136-41.
27. Wen CC, Shyur LF, Jan JT, Liang PH, Kuo CJ, Arulselvan P, Wu JB, Kuo SC, Yang NS. (2011, Aug). Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. Journal of Traditional and Complementary Medicine, 1(1),41-50.
28. Lin YP, Kuo CJ, Koleci X, McDonough SP, Chang YP (2011, Feb). Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding. The Journal of Biological Chemistry, 286(5),3957-69.
2010
29. Ahn TY, Kuo CJ, Liu HG, Ha DC, Liang PH, Jung YS (2010, May). Synthesis and uation of Benzoquinolinone Derivatives as SARS-CoV 3CL Protease Inhibitors. The Korean Chemical Society, 31(1),1-5.
2009
30. Kuo CJ, Shih YP, Kan D, Liang PH (2009, Dec). Engineering a novel endopeptidase based on SARS 3CLpro. Biotechniques, 47 (6),1029-1032.
31. Lee CC#, Kuo CJ#, Ko TP, Hsu MF, Tsui YC, Chang SC, Yang S, Chen SJ, Chen HC, Hsu MC, Shih SR, Liang PH, Wang AH (2009, Mar). Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. The Journal of Biological Chemistry, 284(12),7646-7655.
2008
32. Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH. (2008, Aug). Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. Journal of Biomedicine and Biotechnology, 2008,841312.
33. Kuo CJ, Liu HG, Lo YK, Seong CM, Lee KI, Jung YS, Liang PH (2008, Aug). Individual and common inhibitors of coronavirus and picornavirus main proteases. FEBS Letters, 583(3),549-55..
34. Kuo CJ, Shie JJ, Fang JM, Yen GR, Hsu JT, Liu HG, Tseng SN, Chang SC, Lee CY, Shih SR, Liang PH (2008, Aug). Design, synthesis, and uation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorganic & Medicinal Chemistry, 16(15),7388-98.
2007
35. Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH (2007, Nov). Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Letters, 581(28),5454-8.
36. Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS (2007, Aug). Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of Medicinal Chemistry, 50(17),4087-95.
37. Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. (2007, Jun). Bisphosphonates target multiple sites in both cis- and trans- prenyltransferases.. Proceedings of the National Academy of Sciences, 104(24),10022-7.
2006
38. Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ, Tsai KC, Hsieh HP, Chao YS, Wu SY (2006, Aug). Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. Journal of Medicinal Chemistry, 49(17),5154-61.
39. Wu CY, King KY, Kuo CJ, Fang JM, Wu YT, Ho MY, Liao CL, Shie JJ, Liang PH, Wong CH (2006, Mar). Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chemistry & Biology , 13(3),261-8.
2005
40. Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH (2005, Dec). Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. Journal of Bacteriology , 187(23),8137-48.
41. Hsu MF#, Kuo CJ#, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wang AH, Liang PH (2005, Sep). Mechanism of the maturation process of SARS-CoV 3CL protease. The Journal of Biological Chemistry, 280(35),31257-66.
42. Shie JJ, Fang JM, Kuo TH, Kuo CJ, Liang PH, Huang HJ, Wu YT, Jan JT, Cheng YS, Wong CH (2005, Sep). Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorganic & Medicinal Chemistry, 13(17),5240-52.
43. Chen LR, Wang YC, Lin YW, Chou SY, Chen SF, Liu LT, Wu YT, Kuo CJ, Chen TS, Juang SH (2005, Jun). Synthesis and uation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorganic & Medicinal Chemistry Letters , 15(12),3058-62.
44. Shie JJ, Fang JM, Kuo CJ, Kuo TH, Liang PH, Huang HJ, Yang WB, Lin CH, Chen JL, Wu YT, Wong CH (2005, Jun). Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. Journal of Medicinal Chemistry, 48(13),4469-73.
45. Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH (2005, May). Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. The Journal of Biological Chemistry, 280(21),20762-74.
2004
46. Hsu JT, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CP, Huang PF, Chen X, Liang PH (2004, Sep). uation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Letters, 574(1-3),116-20.
47. Wu CY, Jan JT, Ma SH, Kuo CJ, Juan HF, Cheng YS, Hsu HH, Huang HC, Wu D, Brik A, Liang FS, Liu RS, Fang JM, Chen ST, Liang PH, Wong CH (2004, Jul). Small molecules targeting severe acute respiratory syndrome human coronavirus. Proceedings of the National Academy of Sciences, 101(27),10012-7.
48. Guo RT, Kuo CJ, Ko TP, Chou CC, Liang PH, Wang AH (2004, Jun). A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry, 43(24),7678-86.
49. Kuo CJ, Chi YH, Hsu JT, Liang PH. (2004, Jun). Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochemical and Biophysical Research Communications , 318(4),862-7.
50. Guo RT, Kuo CJ, Chou CC, Ko TP, Shr HL, Liang PH, Wang AH (2004, Feb). Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. The Journal of Biological Chemistry, 279(6),4903-12.
Book Chapters
Christopher P. Ptak, Chih‐Jung Kuo, and Yung‐Fu Chang. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections Mycobacterium tuberculosis Antigen 85 Family Proteins: Mycolyl Transferases and Matrix‐Binding Adhesins (ISBN: 978-1-118-95111-8). WILEY. Nov, 2016.
Patents
Liang PH, Kuo CJ, Shih YP. Protein expression involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease. US patent number: US8053222