關於我

We are interested in studying the interactions between natural compounds (phytochemicals) and cellular proteins. Recently, we focused on colon cancer cells and identified the binding targets of several phytochemicals, like capsaicin and triptolide. Our results clarify the molecular mechanism of tested compounds with a proteomic method, thermal proteome profiling. Possible applications can be extended to future drug development.
If you have functional molecules, like compounds from traditional Thai herbs, we will be very interested in the collaboration of identifying their binding targets.

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領域

Life Sciences、Agriculture and National Resources、Science、Food Science and Biotechnology

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專長

1. Identify the binding targets (proteins) of phytochemicals (or natural compounds) in cancer cells.
2. Proteomic study of protein functional states.
3. Protein-ligand interaction
4. Protein folding and stability
5. Protein engineering

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學歷

• PhD: 2005~2011 Purdue University (USA)
• Medicinal Chemistry and Molecular Pharmacology
• M.S.: 1999~2001 National Chung Kung University
• Biochemistry and Molecular Biology
• B.S.: 1994~1998 National Taiwan Normal University
• Chemistry

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經歷

• Assistant Professor: 2013~now National Chung Hsing University (Department of Food Science & Biotechnology)
• Postdoctoral Researcher: 2011~2013 Duke University (Department of Biochemistry)
• Research Assistant: 2003~2004 Academia Sinica (Institute of Molecular Biology)