1. Kit-Man Fung, Shu-Jung Lai, Tzu-Lu Lin and Tien-Sheng Tseng*. Antigen–Antibody Complex-Guided Exploration of the Hotspots Conferring the Immune-Escaping Ability of the SARS-CoV-2 RBD. Frontiers in Molecular Biosciences.(2022) In press. (impact factor: 5.25)

2. Jangam Vikram Kumar, Tien-Sheng Tseng, Yuan-Chao Lou, Shu-Yi Wei, Tsung-Han Wu, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu*, Chinpan Chen*. Structural insights DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus. Protein science (2022) In press. (Impact factor: 6.75)

3. Min-Che Tung, Kit-Man Fung, Hsin-Mie Hsuc and Tien-Sheng Tseng*. Discovery of 8-Prenylnaringenin from Hop (Humulus lupulus L.) as a potent Monoacylglycerol Lipase Inhibitor for Treatments of Neuroinflammation and Alzheimer’s Disease. RSC Adv. (2021). 11, 31062-31072. (Impact factor: 3.36)(RSC Advances HOT Article Collection)

4. Keng-Chang Tsai, Yu-Ching Lee and Tien-Sheng Tseng*.Comprehensive deep mutational scanning reveals the immune-escaping hotspots of SARS-CoV-2 receptor-binding domain targeting neutralizing antibodies. Frontiers in Microbiology. (2021) 12:698365. doi: 10.3389/fmicb.2021.698365. (Impact factor: 5.64)

5. Min-Che Tung, Keng-Chang Tsai, Kit-Man Fung , Ming-Jaw Don and Tien-Sheng Tseng* Characterizing the Structure-Activity Relationships of Natural Products, Tanshinones, Reveals their Mode of Action in Inhibiting Spleen Tyrosine Kinase. RSC Adv., (2021), 11, 2453-2460. (Impact factor: 3.36)

6. Ping-Sheng Wu, Shu-Jung Lai, Kit-Man Fung and Tien-Sheng Tseng*. Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12. RSC Adv., (2020), 10, 23624. (Impact factor: 3.36)

7. Keng-Chang Tsai, Po-Pin Hung, Ching-Feng Cheng, Chinpan Chen and Tien-Sheng Tseng*. Exploring the mode of action of inhibitors targeting the PhoP response regulator of Salmonella enterica through comprehensive pharmacophore approaches. RSC Adv., (2019), 9, 9308-9312. (Impact factor: 3.36)

8. Tien-Sheng Tseng, I-Fan Tu, Hsiao-Ting Chen, Lie-Chwen Lin, Keng-Chang Tsai, Shih-Hsiung Wu and Chinpan Chen. Protein–DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA. Chemical Communications. (2018) 54, 6372 – 6375.(Impact factory: 6.22)

9. Tien-Sheng Tseng, Keng-Chang Tsai, and Chinpan Chen. Characterizing structure–function relationship reveals mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula. Molecular Bios. (2017) Jun 1;13(6):1193-1201.

10. Tien-Sheng Tseng, Shih-Han Wang, Ting-Wei Chang, Hung-Mu Wei, Yu-June Wang, Keng-Chang Tsai, You-Di Liao and Chinpan Chen. Sarkosyl-induced helical structure of an antimicrobial peptide GW-Q6 plays an essential role in the binding of surface receptor OprI in Pseudomonas aeruginosa. PLoS One (2016) Oct 11;11(10):e0164597.

11. Tien-Sheng Tseng, Show-Mei Chuang, Nai-Wan Hsiao, Yi-Wen, Chen, Yu-Ching Lee, Chi-Chen Lin, Huang C and Keng-Chang Tsai. Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations. Molecular Bios (2016) Jul 19;12(8):2541-51. doi: 10.1039/c6mb00229c.

12. Jine-Yung Huang, Yi-Fang Chiu, José M Ortega, Hsing-Ting Wang, Tien-Sheng Tseng, Shyue-Chu Ke, Mercedes Roncel, Hsiu-An Chu. Mutations of Cytochrome b559 and PsbJ on and near the QC Site in Photo II Influence the Regulation of Short-Term Light Response and Photosynthetic Growth of the Cyanobacterium Synechocystis sp. PCC 6803. Biochemistry. (2016). DOI: 10.1021/acs.biochem.6b00133

13. Tien-Sheng Tseng, Yu-Ching Lee, Nai-Wan Hsiao, Yun-Ru Liue, Keng-Chang Tsai. Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors. Bioorg Med Chem Lett. (2016) Jan 15;26(2):265-71

14. Tien-Sheng Tseng, Keng-Chang Tsai, Wang-Chuan Chen, Yeng-Tseng Wang, Yu-Ching Lee, Chung-Kuang Lu, Ming-Jaw Don, Chang-Yu Chang, ChingHsiao Lee, Hui-Hsiung Lin, Hung-Ju Hsu, and Nai-Wan Hsiao. Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation. J Agric Food Chem. (2015) Jul 15;63(27):6181-8.

15. Wang-Chuan Chen, Tien-Sheng Tseng, Nai-Wan Hsiao, Yun-Lian Lin, Zhi-Hong Wen, Chin-Chuan Tsai, Yu-Ching Lee, Hui-Hsiung Lin & Keng-Chang Tsai. Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling. Sci Rep. (2015) Jan 23;5:7995.

16. Yu-Ching Lee, Nai-Wan Hsiao, Tien-Sheng Tseng, Wang-Chuan Chen, Hui-Hsiung Lin, Sy-Jye Leu, Ei-Wen Yang, Keng-Chang Tsai. Phage Display-Mediated Discovery of Novel Tyrosinase-Targeting Tetrapeptide Inhibitors Reveals the Significance of N-Terminal Preference of Cysteine Residues and Their Functional Sulfur Atom. Mol Pharmacol. (2015) Feb;87(2):218-30.

17. Nai-Wan Hsiao, Tien-Sheng Tseng, Yu-Ching Lee, Wang-Chuan Chen, Hui-Hsiung Lin, Yun-Ru Chen, Yeng-Tseng Wang, Hung-Ju Hsu, and Keng-Chang Tsai. Serendipitous Discovery of Short Peptides from Natural Products as Tyrosinase Inhibitors. J Chem Inf Model. (2014) Nov 24;54(11):3099-111.

18. Tien-Sheng Tseng, Chao-Sheng Cheng, Shang-Te Danny Hsu, Min-Fang Shih, Pei-Lin He, Ping-Chiang Lyu. Residue-Specific Annotation of Disorder-to-Order Transition and Cathepsin Inhibition of a Propeptide-Like Crammer from D. melanogaster. PLoS One. (2013);8(1):e54187.

19. Tien-Sheng Tseng, Chao-Sheng Cheng, Dian-Jiun Chen, Min-Fang Shih, Yu-Nan Yu, Shang-Te Danny Hsu, and Ping-Chiang Lyu. A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin. Biochem J. (2012) Mar 15;442(3):563-72.